Experiences contemporary advancements and development within the carbohydrate-related chemistry of novel nucleic acid mimics and their functions in antisense therapeutics. Discusses using new chemical periods to rationally layout and synthesize oligonucleotides. Explores numerous carbohydrate variations of the oligonucleotide to stabilize opposed to nuclease degradation and to reinforce the binding affinity for a given goal. indicates destiny instructions of carbohydrate-related changes for antisense molecules.
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